✨ The Magnesium Breakthrough You’ve Been Waiting For

We already know magnesium is essential. It’s involved in over 300 enzymatic reactions in the body—from energy production to sleep quality, muscle relaxation, and even hormonal balance. But here’s the question:

What if there were a faster, gentler, and more targeted way to restore magnesium than just popping pills?

🧴 A High-Concentration Spray + Foot Soaks = Surprising Results

In a fascinating pilot study, participants used a 31% magnesium chloride spray twice daily, plus relaxing foot soaks twice a week. Over just 12 weeks, researchers measured what happened inside the body—not just in the blood, but at the cellular level using hair analysis.

The results were striking: 89% of participants showed a meaningful increase in intracellular magnesium. Some increased their magnesium stores by over 200% — a level that typically takes 9–24 months to achieve through oral supplementation.

Below is a list of many more studies that seem to (at least partially) support tangential evidence to further support these findings. One things is for sure, there seems to be a lot trending the way of furthering the idea that topical magnesium being a very valuable form of supplementation.

Summary From Most Searchable Studies

1. Gröber et al. (2017) – Systematic Review

• Design: Literature review of topical magnesium (sprays, baths, creams) vs. oral supplementation.

• Findings: Concluded there’s insufficient evidence supporting superior absorption via skin; most “100% absorption” claims remain unsupported  

2. Cream Absorption Trial (2014)

• Design: 2-week, 56 mg/day magnesium cream vs. placebo.

• Outcome: ~8% serum magnesium increase (statistically significant in non-athletes), supporting some systemic uptake  .

3. Intracellular Uptake via Spray (2013)

• Design: Supersaturated MgCl₂ spray twice daily for 4 months.

• Outcome: ~100% increase in intracellular magnesium (oral mucosa cells); no change in serum meaning topical application enters cells effectively  .

4. 31% MgCl₂ Spray Pilot (2015)

• Design: 12-week pilot using high-concentration spray.

• Outcome: 59.5% increase in intracellular magnesium in 89% of participants—equivalent to 9–24 months of oral supplementation, suggesting up to 5× faster uptake  .

5. Transdermal Trial in Fibromyalgia (2015)

• Design: MgCl₂ spray applied to limbs in fibromyalgia patients (pilot).

• Outcome: Improvements in quality of life, pain, and morning stiffness—suggesting topical magnesium may help musculoskeletal symptoms  .

6. Intravenous vs. Topical in Arterial Thrombosis (Animal Study)

• Design: Rat model comparing IV magnesium and topical cream.

• Outcome: Both methods equally reduced clot formation, though only IV raised serum levels—implying topical benefits may be local  .

7. Dead Sea Water Baths & Skin Barrier (Clinical)

• Design: Human subjects bathed in Dead Sea magnesium-rich water.

• Outcome: Improved skin hydration & barrier function, supporting anti-inflammatory and skin health effects  .

8. Magnesium Balm Review (2025)

• Design: Analysis of balm/spray absorption, including ~8.5% serum rise.

• Outcome: Skin penetration modest; hair follicle areas and cream bases may enhance uptake  .

9. Animal / Cell Studies & Neuroprotection

• Reviews cite magnesium’s action on pain, stress, neuroprotection—but primarily via oral or IV routes, not topical ().

10. Ongoing Pilot Trials

• ClinicalTrials.gov NCT01968772: Pilot of transdermal MgCl₂ in fibromyalgia patients—ongoing  

 What These Studies Imply

• Topical magnesium can be absorbed, particularly at the cellular level—but serum changes are modest.

• Intracellular uptake with sprays (4 mo) and creams (2 wk) is shown, though based on small or pilot studies.

• Benefits reported include improvements in muscle pain, stiffness, skin health, and quality of life—not specifically sleep or hormone regulation. However, studies not listed here/directly linked to topical magnesium have implied that higher amounts of magnesium in the blood correlates with better sleep

• Robust, large RCTs are lacking, especially on sleep, cramps, and systemic hormone outcomes, (but there isn't anything proving the opposite

• Ultimately, there needs to be money behind funding these studies, and at this time, these hasn't been a push for that despite over a decade of reason to believe clinical trials would prove topical magnesium may be even more effective that oral supplementation for some people.

💡 What This Could Mean for You

Magnesium supports:

• ⚡ Energy and mitochondrial function
• 💤 Deeper, more restful sleep
• 🧘♀️ Muscle relaxation and reduced cramping
• 🌿 Hormone regulation & adrenal recovery
• 🧠 Stress resilience and cognitive clarity

While these studies aren't definitive clinical trials as they classify as pilot studies, it leaves the door wide open up for what many of us have already heard about- that transdermal magnesium delivery is a extremely viable option to consider. The skin isn’t just a barrier—it may be a portal.

🌊 Why Transdermal Magnesium Just Makes Sense (to us, and yes, we are not doctors)

Magnesium can be hard to absorb orally, especially if you have digestive sensitivity. That’s why transdermal methods are so compelling: they bypass the gut entirely, delivering minerals directly where your body can use them.

This study hints that daily magnesium rituals—sprays, foot soaks, lotions—may do more than help you feel good. They may actually replenish your body at a deeper level.

🔗 Ready to Feel the Difference?

At Scrub a Lil Deepa, we believe in clean-label, potent skincare—and that includes minerals your body actually craves.

Explore our handcrafted magnesium oil sprays and butters, and build your own soothing ritual. Your skin—and your cells—just might thank you.